Abstract
Encoded Combinatorial Chemistry:
A Tool for the Study of Selective Intermolecular Interactions
Helma Wennemers and W. Clark Still
Department of Chemistry, Columbia University, New York
Encoded combinatorial chemistry allows for the simultaneous generation of a huge number of molecules and their simultaneous screening for desired properties. It has been proven to be a powerful tool for the discovery of selective molecular interactions between hosts and guests that could not have been predicted by conventional means. Using encoded combinatorial chemistry we developed a new class of macrobicyclic two-armed receptors that bind certain tripeptides with extremely high sequence selectivity.1
Furthermore, not only do the two-armed receptors bind with high selectivity to tripeptides but slight variations in the receptor structure also induces significant changes in selectivity. These binding properties make the two-armed receptors to promising lead structures for the design of receptor libraries containing members that bind to a desired peptide selectively.
1 H. Wennemers, S.S. Yoon, W.C. Still, J. Org. Chem. 1995, 60, 1108.
