Abstract
Robert W. Armstrong
The synthesis of combinatorial libraries in which the first several steps
are initiated in solution followed by "resin trapping" for subsequent steps
will be presented. Specifically, libraries based on the triphenylethylene
pharmacophore related on the cinically useful drug tamoxifen will be
discussed. This route provides an entry to the synthesis of mono-, di-,
tri- and tetraphenylethylene structures and their derivatives. A related
strategy will be presented using a convertible or "universal" isocyande to
take advantage of post-Ugi reaction modifications to generate
benzodiazepine diones, pyrroles, and related structures. Several
strategies for library synthesis will also be described.
